First Author | Kang D | Year | 1998 |
Journal | Proc Natl Acad Sci U S A | Volume | 95 |
Issue | 17 | Pages | 10078-82 |
PubMed ID | 9707603 | Mgi Jnum | J:49476 |
Mgi Id | MGI:1277521 | Doi | 10.1073/pnas.95.17.10078 |
Citation | Kang D, et al. (1998) A peptidoglycan recognition protein in innate immunity conserved from insects to humans. Proc Natl Acad Sci U S A 95(17):10078-82 |
abstractText | Innate nonself recognition must rely on common structures of invading microbes. In a differential display screen for up-regulated immune genes in the moth Trichoplusia ni we have found mechanisms for recognition of bacterial cell wall fragments. One bacteria-induced gene encodes a protein that, after expression in the baculovirus system, was shown to be a peptidoglycan recognition protein (PGRP). It binds strongly to Gram-positive bacteria. We have also cloned the corresponding cDNA from mouse and human and shown this gene to be expressed in a variety of organs, notably organs of the immune system- i.e., bone marrow and spleen. In addition, purified recombinant murine PGRP was shown to possess peptidoglycan affinity. From our results and the sequence homology, we conclude that PGRP is a ubiquitous protein involved in innate immunity, conserved from insects to humans. |