| First Author | McDearmon EL | Year | 2006 |
| Journal | FEBS Lett | Volume | 580 |
| Issue | 14 | Pages | 3381-5 |
| PubMed ID | 16709410 | Mgi Jnum | J:200440 |
| Mgi Id | MGI:5508634 | Doi | 10.1016/j.febslet.2006.05.010 |
| Citation | McDearmon EL, et al. (2006) Brain alpha-dystroglycan displays unique glycoepitopes and preferential binding to laminin-10/11. FEBS Lett 580(14):3381-5 |
| abstractText | alpha-Dystroglycan was quantitatively enriched from mammalian brain based on its uniform reactivity with Vicia villosa agglutinin and resolved into sub-populations possessing or lacking the sulfated glucuronic acid epitope recognized by monoclonal antibody HNK-1. We generated a new monoclonal antibody specific for a glycoepitope on brain alpha-dystroglycan but absent from alpha-dystroglycan expressed in all other tissues examined. Finally, we found that laminin-10/11 preferentially bound to brain alpha-dystroglycan compared to skeletal muscle alpha-dystroglycan. Our results suggest that tissue-specific glycosylation modifies the laminin binding specificity of alpha-dystroglycan. |
