| First Author | Kuligina ESh | Year | 1997 |
| Journal | Genetika | Volume | 33 |
| Issue | 11 | Pages | 1529-33 |
| PubMed ID | 9480216 | Mgi Jnum | J:45364 |
| Mgi Id | MGI:1195243 | Citation | Kuligina Esh, et al. (1997) [A comparative genetic analysis of the role of the brain dopaminergic systems in the regulation of behavioral elements in the open field test in DBA/2J and C57BL/6J mice]. Genetika 33(11):1529-33 |
| abstractText | The effects of intraperitoneal injections of sulpiride (10 mg/kg), bromocriptine (5 mg/kg), and alaptide (1 mg/kg) on the behavior of male C57BL/6J (C57BL) and DBA/2J (DBA) mice in the open-field test were studied. In this test, C57BL mice exhibited a significantly higher horizontal locomotor activity than DBA mice, whereas DBA mice moved in place substantially longer than C57BL mice. Dopaminergic agents had different effects on the open-field behavior in different mouse strains. Alaptide increased horizontal locomotor activity in DBA, but not in C57BL mice; all the three agents decreased the duration of movement in place in DBA but not in C57BL mice; bromocriptine suppressed vertical locomotor activity and the act of looking into holes in C57BL but not in DBA mice. Thus, interstrain differences in dopaminergic functions were demonstrated. The revealed strain-specific characteristics largely contribute to the determination of open-field behavior in the studied mouse strains. |
