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Protein Domain : N-acetylmuramic acid 6-phosphate etherase/glucokinase regulatory protein

Primary Identifier  IPR040190 Type  Family
Short Name  MURQ/GCKR
description  N-acetylmuramic acid 6-phosphate etherase (MurQ) is an enzyme involved in peptidoglycan recycling in Escherichia coli. In cyanobacteria MurQ may promote low-light adaptation through peptidoglycan recycling []. MurQ contains a sugar isomerase (SIS) domain with similarity to the glucokinase regulatory protein (GKRP) in humans [].GCKR regulates glucokinase (GK), an enzyme responsible for regulating the uptake and storage of dietary glucose []. In the liver, GKRP forms an inhibitory complex with glucokinase (GCK). The disruption and reformation of this complex occurs in response to direct binding of glucose to GCK, and fructose 1-phosphate (F1P) and fructose 6-phosphate (F6P) to GKRP [].

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4 Protein Domain Regions