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Protein Coding Gene : Prkcd protein kinase C, delta

Primary Identifier  MGI:97598 Organism  mouse, laboratory
Chromosome  14 NCBI Gene Number  18753
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.3.0)

Enables diacylglycerol-dependent serine/threonine kinase activity and insulin receptor substrate binding activity. Involved in several processes, including negative regulation of cellular component organization; negative regulation of insulin receptor signaling pathway; and negative regulation of platelet aggregation. Acts upstream of or within B cell proliferation; immunoglobulin mediated immune response; and positive regulation of apoptotic signaling pathway. Located in several cellular components, including cell-cell junction; cytoplasm; and nuclear matrix. Is expressed in several structures, including alimentary system; central nervous system; early embryo; genitourinary system; and heart and pericardium. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 3; hypertension; and steatotic liver disease. Orthologous to human PRKCD (protein kinase C delta).
PHENOTYPE: Mice homozygous for a null allele exhibit decreased neutrophil cell numbers and activity, increased B cell numbers and proliferation, increased acute inflammation, and increased IgG1 and IgA serum levels. [provided by MGI curators]
  • synonyms:
  • MGD-MRK-13330,
  • MGI:1196301,
  • AI385711,
  • protein kinase C, delta,
  • expressed sequence AI385711,
  • PKCdelta,
  • MGI:2145627,
  • PKC[d],
  • DNA segment, Chr 14, ERATO Doi 420, expressed,
  • D14Ertd420e,
  • Prkcd,
  • Pkcd

Features --> Cross References

Genome

Sequence Feature Displayer

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0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

1 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

43 Pathways

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

3 Driver For