| Primary Identifier | IPR029817 | Type | Family |
| Short Name | PDGF-C |
| description | Platelet-derived growth factor C (PDGF-C) is a pleiotropic molecule with an important role in the regulation of embryonic development, cell proliferation, migration and survival [, , ]. It also plays an important role in angiogenesis and neurovascular interaction [, ].PDGF-C contains an N-terminal CUB domain and a C-terminal domain with homology to members of the PDGF family. PDGF-C is secreted in a latent form. The CUB domain of PDGF-C has to be cleaved extacellularly to make the C-terminal growth factor domain active. After the cleavage, the growth factor domain is able to bind and activate PDGF receptors [, ]. Two proteases are capable of activating PDGF-C: plasmin and tissue plasminogen activator (tPA) [, , ]. The CUB domain has mitogenic activity in coronary artery smooth muscle cells independent of the presence of its C-terminal growth factor domain, suggesting a possible biological activity of the CUB domain itself []. |
