| First Author | Wesemann DR | Year | 2004 |
| Journal | Nat Immunol | Volume | 5 |
| Issue | 2 | Pages | 199-207 |
| PubMed ID | 14730360 | Mgi Jnum | J:87887 |
| Mgi Id | MGI:3028432 | Doi | 10.1038/ni1025 |
| Citation | Wesemann DR, et al. (2004) TRADD interacts with STAT1-alpha and influences interferon-gamma signaling. Nat Immunol 5(2):199-207 |
| abstractText | Tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein (TRADD) is essential in recruiting signaling molecules to the TNFR1 receptor complex. Interferon-gamma (IFN-gamma) is a potent activator of macrophages and uses signal transducer and activator of transcription 1-alpha (STAT1-alpha) for signal transduction. Here we demonstrate that IFN-gamma induces the formation of a nuclear-localized TRADD-STAT1-alpha complex. IFN-gamma-mediated STAT1-alpha phosphorylation was prolonged in cells with reduced TRADD expression. Moreover, we noted an increase in IFN-gamma-mediated STAT1-alpha DNA-binding activity, nuclear presence and transcriptional potential in the TRADD knockdown cells. These data indicate that TRADD may be involved in IFN-gamma signaling by forming a complex with STAT1-alpha within the nucleus and regulating IFN-gamma-mediated STAT1-alpha activation. |
