| First Author | Andrzejewski S | Year | 2017 |
| Journal | Cell Metab | Volume | 26 |
| Issue | 5 | Pages | 778-787.e5 |
| PubMed ID | 28988825 | Mgi Jnum | J:255960 |
| Mgi Id | MGI:6107140 | Doi | 10.1016/j.cmet.2017.09.006 |
| Citation | Andrzejewski S, et al. (2017) PGC-1alpha Promotes Breast Cancer Metastasis and Confers Bioenergetic Flexibility against Metabolic Drugs. Cell Metab 26(5):778-787.e5 |
| abstractText | Metabolic adaptations play a key role in fueling tumor growth. However, less is known regarding the metabolic changes that promote cancer progression to metastatic disease. Herein, we reveal that breast cancer cells that preferentially metastasize to the lung or bone display relatively high expression of PGC-1alpha compared with those that metastasize to the liver. PGC-1alpha promotes breast cancer cell migration and invasion in vitro and augments lung metastasis in vivo. Pro-metastatic capabilities of PGC-1alpha are linked to enhanced global bioenergetic capacity, facilitating the ability to cope with bioenergetic disruptors like biguanides. Indeed, biguanides fail to mitigate the PGC-1alpha-dependent lung metastatic phenotype and PGC-1alpha confers resistance to stepwise increases in metformin concentration. Overall, our results reveal that PGC-1alpha stimulates bioenergetic potential, which promotes breast cancer metastasis and facilitates adaptation to metabolic drugs. |
