| Primary Identifier | MGI:2429701 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Hexb |
| Transmission | Germline | Strain of Origin | 129 |
| Is Recombinase | false | Is Wild Type | false |
| description | ES cell line = CGR8 (129P2/OlaHsd) or R1 ((129X1/SvJ x 129S1/Sv)F1-Kitl+). |
| molecularNote | Exon 2 was disrupted by a neomycin selection cassette inserted by homologous recombination. While transcript was undetected by Northern blot analysis of most tissues, truncated transcript was detected in homozygous mutant testes. Hydrolysis of 4-methylumbelliferyl-Beta-D-acetylglucosamine (MUG) and 4-MUG-6-sulfate (MUGS) were both reduced to 1.5% in homozygous mutant mice. Analysis of the aberrant 1.8 kb transcript showed that it did not contain a neo sequence and indicated that it was non-functional. |
