| First Author | Sabio G | Year | 2005 |
| Journal | EMBO J | Volume | 24 |
| Issue | 6 | Pages | 1134-45 |
| PubMed ID | 15729360 | Mgi Jnum | J:105203 |
| Mgi Id | MGI:3614316 | Doi | 10.1038/sj.emboj.7600578 |
| Citation | Sabio G, et al. (2005) p38gamma regulates the localisation of SAP97 in the cytoskeleton by modulating its interaction with GKAP. EMBO J 24(6):1134-45 |
| abstractText | Activation of the p38 MAP kinase pathways is crucial for the adaptation of mammalian cells to changes in the osmolarity of the environment. Here we identify SAP97/hDlg, the mammalian homologue of the Drosophila tumour suppressor Dlg, as a physiological substrate for the p38gamma MAP kinase (SAPK3/p38gamma) isoform. SAP97/hDlg is a scaffold protein that forms multiprotein complexes with a variety of proteins and is targeted to the cytoskeleton by its association with the protein guanylate kinase-associated protein (GKAP). The SAPK3/p38gamma-catalysed phosphorylation of SAP97/hDlg triggers its dissociation from GKAP and therefore releases it from the cytoskeleton. This is likely to regulate the integrity of intercellular-junctional complexes, and cell shape and volume in response to osmotic stress. |
