| Primary Identifier | MGI:3711772 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Ighm-Ctla4Ig/Cd80)1Jbs |
| Strain of Origin | FVB/N | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | The transgene contains a mouse anti-Ctla4Ig/Cd80 fusion cDNA from which a cell surface bound form of the CD152 antigen (Ctla4Ig) is expressed under control of the IgM heavy chain promoter and enhancer, which directs expression to B cells. To prevent reverse signaling in the transgene expressing cell, the construct was created using a DNA fragment expressing the transmembrane domain from Cd80(B7-1), which lacks the C-terminal, intra-cytoplasmic tail. |
