| First Author | Rutz S | Year | 2015 |
| Journal | Nature | Volume | 518 |
| Issue | 7539 | Pages | 417-21 |
| PubMed ID | 25470037 | Mgi Jnum | J:219495 |
| Mgi Id | MGI:5621075 | Doi | 10.1038/nature13979 |
| Citation | Rutz S, et al. (2015) Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature 518(7539):417-21 |
| abstractText | T-helper type 17 (TH17) cells that produce the cytokines interleukin-17A (IL-17A) and IL-17F are implicated in the pathogenesis of several autoimmune diseases. The differentiation of TH17 cells is regulated by transcription factors such as RORgammat, but post-translational mechanisms preventing the rampant production of pro-inflammatory IL-17A have received less attention. Here we show that the deubiquitylating enzyme DUBA is a negative regulator of IL-17A production in T cells. Mice with DUBA-deficient T cells developed exacerbated inflammation in the small intestine after challenge with anti-CD3 antibodies. DUBA interacted with the ubiquitin ligase UBR5, which suppressed DUBA abundance in naive T cells. DUBA accumulated in activated T cells and stabilized UBR5, which then ubiquitylated RORgammat in response to TGF-beta signalling. Our data identify DUBA as a cell-intrinsic suppressor of IL-17 production. |
