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Protein Coding Gene : Gsdma gasdermin A
Primary Identifier  MGI:1889509 Organism  mouse, laboratory
Chromosome  11 NCBI Gene Number  57911
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Predicted to enable phospholipid binding activity and wide pore channel activity. Predicted to be involved in defense response to bacterium and pyroptosis. Predicted to act upstream of or within programmed cell death. Located in cytoplasm. Is expressed in foregut and skin. Orthologous to human GSDMA (gasdermin A).
PHENOTYPE: Mice homozygous for a null allele exhibit increased susceptibility to bacterial infection with a lack of pyroptosis. [provided by MGI curators]
  • synonyms:
  • Gsdm1,
  • Gsdma,
  • Gsdma1,
  • gasdermin A,
  • Gsdm,
  • BB149167,
  • expressed sequence BB149167,
  • gasdermin 1,
  • MGI:2144607,
  • gasdermin A1,
  • H312E
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0 Canonical

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3 Involved In Mutations

Trail: ProteinCodingGene

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Canonical gene --> Exons in specific strains

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Canonical gene --> Transcripts in specific strains.

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Disease

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