| First Author | Hall AO | Year | 2012 |
| Journal | Immunity | Volume | 37 |
| Issue | 3 | Pages | 511-23 |
| PubMed ID | 22981537 | Mgi Jnum | J:187660 |
| Mgi Id | MGI:5437761 | Doi | 10.1016/j.immuni.2012.06.014 |
| Citation | Hall AO, et al. (2012) The Cytokines Interleukin 27 and Interferon-gamma Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology. Immunity 37(3):511-23 |
| abstractText | Interferon-gamma (IFN-gamma) promotes a population of T-bet(+) CXCR3(+) regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL-27) also promoted expression of T-bet and CXCR3 in Treg cells. During infection with Toxoplasma gondii, a similar population emerged that limited T cell responses and was dependent on IFN-gamma in the periphery but on IL-27 at mucosal sites. Transfer of Treg cells ameliorated the infection-induced pathology observed in Il27(-/-) mice, and this was dependent on their ability to produce IL-10. Microarray analysis revealed that Treg cells exposed to either IFN-gamma or IL-27 have distinct transcriptional profiles. Thus, IFN-gamma and IL-27 have different roles in Treg cell biology and IL-27 is a key cytokine that promotes the development of Treg cells specialized to control Th1 cell-mediated immunity at local sites of inflammation. |
