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Publication : HIF-1alpha is necessary to support gluconeogenesis during liver regeneration.

First Author  Tajima T Year  2009
Journal  Biochem Biophys Res Commun Volume  387
Issue  4 Pages  789-94
PubMed ID  19643083 Mgi Jnum  J:152724
Mgi Id  MGI:4359567 Doi  10.1016/j.bbrc.2009.07.115
Citation  Tajima T, et al. (2009) HIF-1alpha is necessary to support gluconeogenesis during liver regeneration. Biochem Biophys Res Commun 387(4):789-94
abstractText  Coordinated recovery of hepatic glucose metabolism is prerequisite for normal liver regeneration. To examine roles of hypoxia inducible factor-1alpha (HIF-1alpha) for hepatic glucose homeostasis during the reparative process, we inactivated the gene in hepatocytes in vivo. Following partial hepatectomy (PH), recovery of residual liver weight was initially retarded in the mutant mice by down-regulation of hepatocyte proliferation, but occurred comparably between the mutant and control mice at 72h after PH. At this time point, the mutant mice showed lowered blood glucose levels with enhanced accumulation of glycogen in the liver. The mutant mice exhibited impairment of hepatic gluconeogenesis as assessed by alanine tolerance test. This appeared to result from reduced expression of PGK-1 and PEPCK since 3-PG, PEP and malate were accumulated to greater extents in the regenerated liver. In conclusion, these findings provide evidence for roles of HIF-1alpha in the regulation of gluconeogenesis under liver regeneration.
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