| First Author | Bielefeld KA | Year | 2011 |
| Journal | J Biol Chem | Volume | 286 |
| Issue | 31 | Pages | 27687-97 |
| PubMed ID | 21652705 | Mgi Jnum | J:175376 |
| Mgi Id | MGI:5285460 | Doi | 10.1074/jbc.M111.261677 |
| Citation | Bielefeld KA, et al. (2011) Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing. J Biol Chem 286(31):27687-97 |
| abstractText | beta-Catenin is an important regulator of dermal fibroblasts during cutaneous wound repair. However, the factors that modulate beta-catenin activity in this process are not completely understood. We investigated the role of the extracellular matrix in regulating beta-catenin and found an increase in beta-catenin-mediated Tcf-dependent transcriptional activity in fibroblasts exposed to various extracellular matrix components. This occurs through an integrin-mediated GSK3beta-dependent pathway. The physiologic role of this mechanism was demonstrated during wound repair in extra domain A-fibronectin-deficient mice, which exhibited decreased beta-catenin-mediated signaling during the proliferative phase of healing. Extra domain A-fibronectin-deficient mice have wounds that fail at a lower tensile strength and contain fewer fibroblasts compared with wild type mice. This phenotype was rescued by genetic or pharmacologic activation of beta-catenin signaling. Because fibronectin is a transcriptional target of beta-catenin, this suggests the existence of a feedback loop between these two molecules that regulates dermal fibroblast cell behavior during wound repair. |
