| First Author | Lin CY | Year | 2002 |
| Journal | Nat Immunol | Volume | 3 |
| Issue | 12 | Pages | 1208-13 |
| PubMed ID | 12415266 | Mgi Jnum | J:151745 |
| Mgi Id | MGI:4355134 | Doi | 10.1038/ni853 |
| Citation | Lin CY, et al. (2002) Dominant transplantation tolerance impairs CD8+ T cell function but not expansion. Nat Immunol 3(12):1208-13 |
| abstractText | Alloreactive CD8+ T cells may persist in animals made tolerant of transplanted tissues; their function is controlled through continuous censorship by regulatory CD4+ T cells. We sought to establish the stage at which such censorship operates. We found that monospecific CD8+ T cells introduced into tolerant animals responded to the tolerated tissue antigen as if they had received CD4+ T cell 'help': they proliferated and accumulated normally. However, they did show compromised graft rejection, interferon-gamma production and cell-mediated cytotoxicity. These findings suggest that tolerance mediated by regulatory T cells acts by censoring immune effector functions rather than by limiting the induction of T cell responses. |
