| First Author | Tian T | Year | 2011 |
| Journal | Int J Biol Sci | Volume | 7 |
| Issue | 2 | Pages | 234-43 |
| PubMed ID | 21448284 | Mgi Jnum | J:286335 |
| Mgi Id | MGI:6403370 | Doi | 10.7150/ijbs.7.234 |
| Citation | Tian T, et al. (2011) TDP-43 potentiates alpha-synuclein toxicity to dopaminergic neurons in transgenic mice. Int J Biol Sci 7(2):234-43 |
| abstractText | TDP-43 and alpha-synuclein are two disease proteins involved in a wide range of neurodegenerative diseases. While TDP-43 proteinopathy is considered a pathologic hallmark of sporadic amyotrophic lateral sclerosis and frontotemporal lobe degeneration, alpha-synuclein is a major component of Lewy body characteristic of Parkinson's disease. Intriguingly, TDP-43 proteinopathy also coexists with Lewy body and with synucleinopathy in certain disease conditions. Here we reported the effects of TDP-43 on alpha-synuclein neurotoxicity in transgenic mice. Overexpression of mutant TDP-43 (M337V substitution) in mice caused early death in transgenic founders, but overexpression of normal TDP-43 only induced a moderate loss of cortical neurons in the transgenic mice at advanced ages. Interestingly, concomitant overexpression of normal TDP-43 and mutant alpha-synuclein caused a more severe loss of dopaminergic neurons in the double transgenic mice as compared to single-gene transgenic mice. TDP-43 potentiated alpha-synuclein toxicity to dopaminergic neurons in living animals. Our finding provides in vivo evidence suggesting that disease proteins such as TDP-43 and alpha-synuclein may play a synergistic role in disease induction in neurodegenerative diseases. |
