| First Author | Park SH | Year | 1995 |
| Journal | Oncogene | Volume | 11 |
| Issue | 11 | Pages | 2349-55 |
| PubMed ID | 8570186 | Mgi Jnum | J:45479 |
| Mgi Id | MGI:1195509 | Citation | Park SH, et al. (1995) A putative effector of Ral has homology to Rho/Rac GTPase activating proteins. Oncogene 11(11):2349-55 |
| abstractText | We report here the cloning of a gene encoding a novel Ral interacting protein (RIP1) from a cDNA expression library using radiolabeled Ral as probe. RIP1 binds to Ral in a GTP-dependent manner. The 4.1 kb transcript of the RIP1 gene is present in all tissues analysed and encodes for a protein product of 648 residues. RIP1 shares sequence similarity with GAP proteins that are capable of activating the GTPase activity of members of the Rho/Rac family of GTPases. When tested, RIP1 could activate the GTPase activity of CDC42 and, to a lesser extent, Rac1 but not RhoA, Ras, or Ral. Activated Ral had no effect on the GTPase-activating ability of RIP1, in vitro. |
