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Allele : Hbb<tm3(HBG1,HBB)Tow> hemoglobin beta chain complex; targeted mutation 3, Timothy Townes
Primary Identifier  MGI:3790756 Allele Type  Targeted
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Hbb
Transmission  Germline Strain of Origin  Not Specified
Is Recombinase  false Is Wild Type  false
molecularNote  In ES cells that were homozygous for Hbatm1(HBA)Tow and Hbbtm2(HBG1,HBB*)Tow the human gamma chain and beta chain containing the sickle cell mutation (an A to T transversion in the sixth codon) were replaced with the human gamma chain, beta chain (lacking the sickle cell mutation) and 383 bp of sequence flanking the gamma chain. Cre-mediated recombination removed the floxed hygro cassette.
  • mutations:
  • Insertion,
  • Intergenic deletion
  • synonyms:
  • -383 gamma-beta<A>,
  • -383 gamma-beta<A>,
  • Hbb<tm3(HBB)Tow>,
  • Hbb<tm3(HBB)Tow>
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1 Feature

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2 Expresses

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2 Mutation Involves

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Phenotype

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1 Driven By

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