| First Author | Davis RS | Year | 2004 |
| Journal | Int Immunol | Volume | 16 |
| Issue | 9 | Pages | 1343-53 |
| PubMed ID | 15302849 | Mgi Jnum | J:91959 |
| Mgi Id | MGI:3051197 | Doi | 10.1093/intimm/dxh137 |
| Citation | Davis RS, et al. (2004) Differential B cell expression of mouse Fc receptor homologs. Int Immunol 16(9):1343-53 |
| abstractText | Five Fc receptor homologs (FcRH1-5) possessing inhibitory and/or activating signaling motifs are differentially expressed during B cell differentiation in humans. In this analysis we describe their three mouse orthologs, moFcRH1, moFcRH2 and moFcRH3. The moFcRH genes are located in a chromosome 3 region that is syntenic with the FcRH locus on human chromosome 1. They encode proteins with 2-5 Ig-like domains that share 20-61% extracellular identity with their human counterparts. One moFcRH1 isoform lacks a transmembrane domain as do both moFcRH2 isoforms. The other moFcRH1 isoform and two moFcRH3 isoforms have transmembrane domains and cytoplasmic ITIM and ITAM-like consensus sequences implying their inhibitory or activating signaling potential. Whereas the moFcRH1 and moFcRH3 orthologs are preferentially expressed at different stages in B cell differentiation, the structurally novel moFcRH2 gene is expressed in non-lymphoid tissues. The highly restricted pattern of moFcRH3 expression suggests this member of the phylogenetically conserved FcRH family may have an important immunoregulatory role in marginal zone B cells. |
