| First Author | Shirane M | Year | 2006 |
| Journal | Science | Volume | 314 |
| Issue | 5800 | Pages | 818-21 |
| PubMed ID | 17082457 | Mgi Jnum | J:114677 |
| Mgi Id | MGI:3689747 | Doi | 10.1126/science.1134027 |
| Citation | Shirane M, et al. (2006) Protrudin induces neurite formation by directional membrane trafficking. Science 314(5800):818-21 |
| abstractText | Guanosine triphosphatases of the Rab family are key regulators of membrane trafficking, with Rab11 playing a specific role in membrane recycling. We identified a mammalian protein, protrudin, that promoted neurite formation through interaction with the guanosine diphosphate (GDP)-bound form of Rab11. Phosphorylation of protrudin by extracellular signal-regulated kinase (ERK) in response to nerve growth factor promoted protrudin association with Rab11-GDP. Down-regulation of protrudin by RNA interference induced membrane extension in all directions and inhibited neurite formation. Thus, protrudin regulates Rab11-dependent membrane recycling to promote the directional membrane trafficking required for neurite formation. |
