| First Author | Griswold DP | Year | 1975 |
| Journal | Cancer | Volume | 36 |
| Issue | 6 Suppl | Pages | 2441-4 |
| PubMed ID | 1212662 | Mgi Jnum | J:48908 |
| Mgi Id | MGI:1277525 | Doi | 10.1002/1097-0142(197512)36:6<2441::aid-cncr2820360627>3.0.co;2-p |
| Citation | Griswold DP, et al. (1975) A colon tumor model for anticancer agent evaluation. Cancer 36(6 Suppl):2441-4 |
| abstractText | Colon tumors of mice were induced with 1, 2-dimethylhydrazine, N-nitroso-N-methylurethane, methylnitrosourea, and 4-methyl-N'-nitro-N-nitrosoguanidine. Of 82 transplantation attempts, four were successful, and the four tumors have been maintained as distinct tumor lines by subcutaneous transplantation. The tumors graded from II, adenocarcinoma, to IV, undifferentiated carcinoma. Volume-doubling times varied over a three-fold range, and metastatic potential ranged from 5 to about 100%. The tumors responded to treatment with some of the same agents found to be active in man. These included cyclophosphamide, 5-fluorouracil, and certain nitrosoureas. Preliminary evidence suggests that these tumor lines may be useful as experimental models. |
