| Primary Identifier | MGI:109185 | Organism | mouse, laboratory |
| Chromosome | 15 | NCBI Gene Number | 18133 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable Notch binding activity; heparin binding activity; and integrin binding activity. Involved in several processes, including bone regeneration; negative regulation of insulin secretion; and type B pancreatic cell proliferation. Acts upstream of with a positive effect on negative regulation of SMAD protein signal transduction. Located in extracellular space. Is expressed in several structures, including cardiovascular system; central nervous system; genitourinary system; gut; and sensory organ. Orthologous to human CCN3 (cellular communication network factor 3). PHENOTYPE: Heterozygotes and homozygotes for a null mutation exhibit abnormal skeletal and cardiac development, muscle atrophy and cataracts. Mice homozygous for another knock-out allele exhibit minor bone structure and physiology defects. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
