Primary Identifier | MGI:3054888 | Allele Type | Targeted |
Attribute String | Null/knockout | Gene | Cd22 |
Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
Is Recombinase | false | Is Wild Type | false |
molecularNote | Exons 3 and 4 were deleted following Cre-mediated excision of a floxed neo. A 3' mRNA splice junction of exon 3 was retained. Immunoblot and flow cytometry confirmed protein expression by B cells. Protein migrated as a 120 kDa fragment, the predicted size of the protein lacking two immunoglobulin-like domains. |