| First Author | Hamaguchi I | Year | 1996 |
| Journal | Biochem Biophys Res Commun | Volume | 224 |
| Issue | 1 | Pages | 172-9 |
| PubMed ID | 8694808 | Mgi Jnum | J:34080 |
| Mgi Id | MGI:81554 | Doi | 10.1006/bbrc.1996.1003 |
| Citation | Hamaguchi I, et al. (1996) Analysis of CSK homologous kinase (CHK/HYL) in hematopoiesis by utilizing gene knockout mice. Biochem Biophys Res Commun 224(1):172-9 |
| abstractText | CHK/HYL is a non-receptor tyrosine kinase that belongs to CSK (C-terminal Src kinase) family. Northern blotting and RT-PCR analyses showed that CHK/HYL was expressed in large spectrum of hematopoietic cells except for erythroid cells and brain. To explore the function of CHK/HYL in hematopoietic cells, we generated CHK/HYL deficient mice. The mutant mice were apparently normal and fertile, while CSK knockout mice died until E11.5 from a defect in the neural tube formation. Hematological observations including blood counts and PACS analysis showed no significant abnormalities in CHK/HYL mutant mice. CHK/HYL did not affect the activity of Src, Hck, and Fgr in cultured bone marrow cells, although CSK negatively regulates Src family kinases, These results suggest that CHK/HYL might not have the same function as CSK. (C) 1996 Academic Press, Inc. |
