| Type | MGI:General | Description | at 24 weeks of age, mice showed increased hepatic lipogenic gene and protein expression relative to wild-type controls in the fasted state, hepatic levels of active SREBP-1c (a master lipogenic transcription factor) in the nucleus were significantly higher than those in wild-type controls following incubation with oleic acid (OA), primary hepatocytes isolated from fasted mice showed increased de novo lipogenesis with an increased number of lipid droplets and higher lipid (TG) mass but similar incorporation of OA into different lipid species relative to wild-type hepatocytes incubation of hepatocytes with EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) reversed the increased lipogenic phenotype; the anti-lipogenic effect was mediated by lower nuclear SREBP-1c upon PUFA (polyunsaturated fatty acids) treatment |
