| First Author | Dannecker G | Year | 1993 |
| Journal | Immunobiology | Volume | 187 |
| Issue | 1-2 | Pages | 17-23 |
| PubMed ID | 8099340 | Mgi Jnum | J:11833 |
| Mgi Id | MGI:60103 | Doi | 10.1016/s0171-2985(11)80242-1 |
| Citation | Dannecker G, et al. (1993) Differential expression of T cell receptor variable beta genes on CD4+ and CD8+ T cells: influence by sex linked genes?. Immunobiology 187(1-2):17-23 |
| abstractText | We examined the expression of seven V alpha or V beta T cell receptor (TCR) segments on human CD4+ and CD8+ T cells. Confirming previously published results, we found a preferential expression of four V segment gene products on CD4+ T cells. One of these markers (V beta 6.7) was constantly expressed on more CD4+ T cells than CD8+ T cells. None of the analyzed blood samples showed a complete deletion of T cells expressing a particular V beta gene segment. In addition, our data provide the first evidence that genes on sex chromosomes may influence the formation of the human T cell repertoire. The ratio of CD4+/CD8+ T cells expressing V beta 12 gene products was always > or = 1 in female donors, whereas approximately 30% male donors exhibited more CD8+V beta 12+ T cells than CD4+V beta 12+ T cells. |
