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Comment :

Type  MGI:General Description  the number of PH3+ mitotic cells is normal at E12.5 but markedly increased in the developing cortex at E14.5 and E17.5 the percentage of ventricular zone (VZ) cells in prophase and pro-metaphase is significantly increased at E12.5, suggesting that the increase and abnormal distribution of mitotic cells might be due to cell cycle arrest although total number of proliferative radial glia cells (RGs) is normal at E14.5, the percentage of RGs at mitotic phase is increased, indicating a mitotic delay in RGs at the VZ live imaging of mitotic RGs in cultured E13.5 brain slices revealed a higher percentage of RGs with prolonged M-phase duration (>60 min/mitotic cell) analysis of the division angles of RGs at the VZ region demonstrated that neural progenitors (NPs) show an increase in oblique division (30-60 degrees) at the cost of near-vertical division (60-90 degrees) at E13.5 prolonged mitosis of ventricular RGs causes a marked reduction in the production of deep layer neurons