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Publication : Impaired spatial memory and altered dendritic spine morphology in angiotensin II type 2 receptor-deficient mice.

First Author  Maul B Year  2008
Journal  J Mol Med (Berl) Volume  86
Issue  5 Pages  563-71
PubMed ID  18335189 Mgi Jnum  J:267180
Mgi Id  MGI:6258314 Doi  10.1007/s00109-008-0316-4
Citation  Maul B, et al. (2008) Impaired spatial memory and altered dendritic spine morphology in angiotensin II type 2 receptor-deficient mice. J Mol Med (Berl) 86(5):563-71
abstractText  Mental retardation is the most frequent cause of serious handicap in children and young adults. Mutations in the human angiotensin II type 2 receptor (AT2) have been implicated in X-linked forms of mental retardation. We here demonstrate that mice lacking the AT2 receptor gene are significantly impaired in their performance in a spatial memory task and in a one-way active avoidance task. As no difference was observed between the genotypes in fear conditioning, the detected deficit in spatial memory may not relate to fear. Notably, receptor knockout mice showed increased motility in an activity meter and elevated plus maze. Importantly, these mice are characterized by abnormal dendritic spine morphology and length, both features also found to be associated with some cases of mental retardation. These findings suggest a crucial role of AT2 in normal brain function and that dysfunction of the receptor has impact on brain development and ultrastructural morphology with distinct consequences on learning and memory.
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