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Protein Coding Gene : Smarca1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1

Primary Identifier  MGI:1935127 Organism  mouse, laboratory
Chromosome  X NCBI Gene Number  93761
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables chromatin binding activity. Involved in neuron differentiation. Acts upstream of or within brain development and regulation of neural precursor cell proliferation. Part of chromatin. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Orthologous to human SMARCA1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1).
PHENOTYPE: Female mice homozygous and male mice hemizygous for a targeted disruption of this gene exhibit abnormalities in neuron differentiation and neuronal precursor proliferation, increased brain and heart weight, and forebrain hypercellularity. [provided by MGI curators]
  • synonyms:
  • MGI:2444083,
  • Smarca1,
  • 5730494M04Rik,
  • Snf2l,
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1,
  • RIKEN cDNA 5730494M04 gene

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Genome

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Canonical gene --> Transcripts in specific strains.

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