| Type | MGI:General | Description | 15% and 44% decrease in maximal force in skinned muscle fibers of 3 and 7 month old mice, respectively compared to wild-type mice indicating reduced contractile force slight, but significant, decrease in the calcium sensitivity of force in muscle fibers the fraction of total myosin cross-bridges that can attach to actin during maximal calcium activation is decreased about 15% in the myocardium |
