| Primary Identifier | MGI:3616888 | Allele Type | Chemically induced (ENU) |
| Gene | Tnf | Inheritance Mode | Dominant |
| Strain of Origin | C57BL/6J | Is Recombinase | false |
| Is Wild Type | false | Project Collection | Beutler Mutagenetix |
| molecularNote | This mutation was identified in a screen of G1 progeny of ENU mutagenized male mice for responses to Toll-like receptor- (TLR-) activating ligands. It is a C-to-A transversion in exon 4 which results in replacement of proline by threonine at amino acid 138 of the protein (P138T). Mutant mice produce no active TNF, either secreted or membrane-bound. |
