| First Author | Chestier A | Year | 1992 |
| Journal | DNA Seq | Volume | 2 |
| Issue | 5 | Pages | 325-7 |
| PubMed ID | 1633330 | Mgi Jnum | J:44873 |
| Mgi Id | MGI:1101419 | Doi | 10.3109/10425179209030966 |
| Citation | Chestier A, et al. (1992) Difference in the genomic organizations of the related transcription factors Sp1 and Krox-20; possible evolutionary significance. DNA Seq 2(5):325-7 |
| abstractText | We report here part of the genomic sequence of the mouse homolog of the human gene encoding the transcription factor Sp1. This gene belongs to a subfamily of zinc finger proteins, which includes another transcription factor, Krox-20. The analysis of the mouse Sp1 nucleotide sequence revealed that (i) the C-terminal part of the protein is conserved between man and mouse, consistent with a possible role in transcriptional activation; (ii) while the there Krox-20 zinc fingers are encoded by a unique exon, an intron separates the regions encoding fingers 2 and 3 of Sp1. On the basis of this latter observation, we propose a model for the evolution of the Sp1/Krox-20 gene family which might shed some light on the role of introns in the evolution of modular proteins. |
