| First Author | Xuan S | Year | 2002 |
| Journal | J Clin Invest | Volume | 110 |
| Issue | 7 | Pages | 1011-9 |
| PubMed ID | 12370279 | Mgi Jnum | J:79805 |
| Mgi Id | MGI:2388956 | Doi | 10.1172/JCI15276 |
| Citation | Xuan S, et al. (2002) Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. J Clin Invest 110(7):1011-9 |
| abstractText | Defective insulin secretion is a feature of type 2 diabetes that results from inadequate compensatory increase of beta cell mass and impaired glucose-dependent insulin release. beta cell proliferation and secretion are thought to be regulated by signaling through receptor tyrosine kinases. In this regard, we sought to examine the potential proliferative and/or antiapoptotic role of IGFs in beta cells by tissue-specific conditional mutagenesis ablating type 1 IGF receptor (IGF1R) signaling. Unexpectedly, lack of functional IGF1R did not affect beta cell mass, but resulted in age-dependent impairment of glucose tolerance, associated with a decrease of glucose- and arginine-dependent insulin release. These observations reveal a requirement of IGF1R-mediated signaling for insulin secretion. |
