| First Author | Feng JQ | Year | 1997 |
| Journal | Biochim Biophys Acta | Volume | 1350 |
| Issue | 1 | Pages | 47-52 |
| PubMed ID | 9003457 | Mgi Jnum | J:37865 |
| Mgi Id | MGI:85261 | Doi | 10.1016/s0167-4781(96)00178-9 |
| Citation | Feng JQ, et al. (1997) Bone morphogenetic protein 2 transcripts in rapidly developing deer antler tissue contain an extended 5' non-coding region arising from a distal promoter. Biochim Biophys Acta 1350(1):47-52 |
| abstractText | To understand the regulation of the BMP-2 gene expression, we recently isolated the BMP-2 gene from a mouse genomic library and characterized the exon-intron structure and promoter. RNase protection assay using poly (A)+ RNA of mouse osteoblasts demonstrates that two regions in BMP-2 gene are protected by antisense mouse BMP-2 RNA probes. These results demonstrate that BMP-2 gene utilizes two alternative promoters, a distal and a proximal promoter. In the present study we demonstrate that BMP-2 mRNA from rapidly growing deer antler tissue has an extended 5' non-coding region compared with the human and rat BMP-2 mRNA. The extended 5' non-coding region in the deer mRNA represents transcripts from the upstream distal promoter. This is the first evidence of a natural BMP-2 mRNA from a bone-forming tissue that most likely initiated from the distal transcription start site. |
