| Type | MGI:General | Description | tumor incidence is dramatically increased in gamma-irradiated heterozygotes (85% vs 41% in wild-type control mice), with more lymphomas and epithelial tumors detected in radiation-treated heterozygotes relative to wild-type controls or to unirradiated groups more lymphomas and epithelial tumors are observed in radiation-treated heterozygotes relative to wild-type controls or to unirradiated groups gamma-irradiation induces a high frequency of thyroid gland atypical hyperplasia and intraepithelial adenomas, and enhances the formation of lung cancers, germ cell tumors and stromal cell tumors in the testis (Leydig cell tumors) and ovary |
