| First Author | Edelson BT | Year | 2001 |
| Journal | Immunity | Volume | 14 |
| Issue | 5 | Pages | 503-12 |
| PubMed ID | 11371353 | Mgi Jnum | J:69470 |
| Mgi Id | MGI:1934701 | Doi | 10.1016/s1074-7613(01)00139-x |
| Citation | Edelson BT, et al. (2001) Intracellular antibody neutralizes listeria growth. Immunity 14(5):503-12 |
| abstractText | We previously reported that treatment of mice with a neutralizing mAb against listeriolysin O (LLO), the pore-forming toxin of Listeria monocytogenes, provided resistance to this intracellular bacterium. We evaluated whether anti-LLO mAb would affect Listeria handling by macrophages, essential cells in Listeria resistance. Macrophages infected in the presence of anti-LLO mAb showed a marked reduction in intracellular Listeria growth, with a concomitant block in LLO-dependent Listeria passage from phagosome to cytosol. Anti-LLO mAb did not opsonize Listeria but, rather, acted within macrophages to neutralize LLO. Importantly, anti-LLO mAb effects on Listeria growth were independent of Fcgamma receptor expression, IFNgamma signaling, and production of nitric oxide and superoxide. These results identify a novel mechanism for antibody control of bacteria within macrophages. |
