|  Help  |  About  |  Contact Us

Protein Coding Gene : Itgb5 integrin beta 5
Primary Identifier  MGI:96614 Organism  mouse, laboratory
Chromosome  16 NCBI Gene Number  16419
Mgi Type  protein coding gene
description  FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0)

Enables integrin binding activity. Involved in integrin-mediated signaling pathway; stress fiber assembly; and transforming growth factor beta receptor signaling pathway. Located in cell leading edge and focal adhesion. Part of integrin alphav-beta5 complex. Is active in glutamatergic synapse and synaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; embryo mesenchyme; and genitourinary system. Orthologous to human ITGB5 (integrin subunit beta 5).
PHENOTYPE: Homozygotes for a targeted null mutation do not appear to differ from normal in respect to development, reproduction, adenovirus infection, or wound healing. Mutant keratinocytes do show reduced migration on, and adhesion to, vitronectin in vitro. [provided by MGI curators]
  • synonyms:
  • EST AA475909,
  • integrin beta 5,
  • [b]-5,
  • ESTM23,
  • AI874634,
  • AA475909,
  • [b]5B,
  • MGD-MRK-11493,
  • MGI:2146516,
  • [b]5A,
  • expressed sequence AI874634,
  • [b]5,
  • MGI:1201382,
  • Itgb5,
  • expressed sequence tag mouse EST 23,
  • beta-5,
  • beta5
Paste the following link
Lists
This ProteinCodingGene isn't in any lists. Upload a list.

Features --> Cross References

Genome

Sequence Feature Displayer

JG Browse Displayer

0 Canonical

0 CDSs

0 Exons

0 Genomic Clusters

0 Involved In Mutations

0 Strain

0 Transcripts

0 Transgenic Expressors

0 UTRs

Canonical gene --> CDSs in specific strains.

Canonical gene --> Exons in specific strains

Canonical gene --> Strain-specific IDs, biotypes, and locations

Canonical gene --> Transcripts in specific strains.

Features --> Overlapping features

Proteins

Gene --> Proteins

Function

Mouse features --> Functions (GO terms)

Homology

Genes --> Homologs

Interactions

18 Pathways

Trail: ProteinCodingGene

0 Targeted By

Gene --> Protein-Protein Interactions

Expression

Gene --> Expression annotations

Phenotype

Genes/Features --> Phenotypes (MP terms)

Disease

Mouse features --> Human diseases

Literature

Mouse features --> Publications

 

Other

0 Driver For





MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom