| Primary Identifier | IPR040457 | Type | Domain |
| Short Name | GCP_C |
| description | This is the C-terminal domain found in components of the gamma-tubulin complex proteins (GCPs). Family members include spindle pole body (SBP) components such as Spc97 and Spc98 which function as the microtubule-organizing centre in yeast []. Furthermore, family members such as human GCP4 (gamma-tubulin complex component 4) have been structurally elucidated (). Structure-based sequence analysis revealed the existence of an exposed surfacearea conserved in all human GCPs and in GCP4 orthologues. This area is located in the C-terminal domain of GCP4, which was confirmed in vitro to bind directly to gamma-tubulin. Sequence alignment of human GCPs based on the GCP4 structure helped delineate conserved regions in the N- and C-terminal domains []. |
