| First Author | Zuberi AR | Year | 1998 |
| Journal | Immunity | Volume | 9 |
| Issue | 5 | Pages | 687-98 |
| PubMed ID | 9846490 | Mgi Jnum | J:51335 |
| Mgi Id | MGI:1315112 | Doi | 10.1016/s1074-7613(00)80666-4 |
| Citation | Zuberi AR, et al. (1998) Positional cloning and molecular characterization of an immunodominant cytotoxic determinant of the mouse H3 minor histocompatibility complex. Immunity 9(5):687-98 |
| abstractText | Immune responses to minor histocompatibility antigens are poorly understood and present substantial barriers to successful solid tissue and bone marrow transplantation among MHC-matched individuals. We exploited a unique positional cloning approach relying on the potent negative selection capability of cytotoxic T cells to identify the H3a gene responsible for immunodominant H2-Db-restricted determinants of the classically defined mouse autosomal H3 complex. The allelic basis for reciprocal H3a antigens is two amino acid changes within a single nonamer H2-Db-binding peptide. The H3a gene, now called Zfp106, encodes a 1888-amino acid protein with three zinc fingers and a beta-transducin domain consistent with DNA/protein binding. A region of ZFP106 is identical to a 600-amino acid sequence implicated in the insulin receptor signaling pathway. |
