| First Author | Sumida H | Year | 2018 |
| Journal | Front Immunol | Volume | 9 |
| Pages | 660 | PubMed ID | 29670628 |
| Mgi Jnum | J:272224 | Mgi Id | MGI:6281237 |
| Doi | 10.3389/fimmu.2018.00660 | Citation | Sumida H, et al. (2018) G-Protein Coupled Receptor 18 Contributes to Establishment of the CD8 Effector T Cell Compartment. Front Immunol 9:660 |
| abstractText | The requirements for effector and memory CD8 T cell development are incompletely understood. Recent work has revealed a role for G-protein coupled receptor 18 (GPR18) in establishment of the intestinal CD8alphaalpha intraepithelial lymphocyte compartment. Here, we report that GPR18 is also functionally expressed in conventional CD8alphabeta T cells. When the receptor is lacking, mice develop fewer CD8(+) KLRG1(+) Granzyme B(+) effector-memory cells. Bone marrow chimera studies show that the GPR18 requirement is CD8 T cell intrinsic. GPR18 is not required for T-bet expression in KLRG1(+) CD8 T cells. Gene transduction experiments confirm the functional activity of GPR18 in CD8 T cells. In summary, we describe a novel GPCR requirement for establishment or maintenance of the CD8 KLRG1(+) effector-memory T cell compartment. These findings have implications for methods to augment CD8 effector cell numbers. |
