| First Author | Miyamoto T | Year | 2003 |
| Journal | Dev Genes Evol | Volume | 213 |
| Issue | 4 | Pages | 199-202 |
| PubMed ID | 12684778 | Mgi Jnum | J:84010 |
| Mgi Id | MGI:2664594 | Doi | 10.1007/s00427-003-0313-0 |
| Citation | Miyamoto T, et al. (2003) Molecular cloning and expression analysis of the mouse Spot-2 gene in pituitary development. Dev Genes Evol 213(4):199-202 |
| abstractText | Mouse Spot-1 is a DNA-binding protein with a domain (His-Thr) encoded by p(CA)n repeats. Spot-1 interacts with the nuclear localization signal (NLS) I of p53 through its His-Thr domain. In this study we describe the cloning and expression patterns of a novel gene encoding a protein containing a His-Thr domain, Spot-2. Spot-2 is exclusively expressed in the pituitary from stage E13.5 to E15.5. Mouse Lhx3 plays a critical role during early organogenesis in the pituitary. The Spot-2 gene appears to be a downstream gene of Lhx3. It is suggested that Spot-2 plays important roles in pituitary development. |
