| First Author | Ishiguro K | Year | 2011 |
| Journal | EMBO Rep | Volume | 12 |
| Issue | 3 | Pages | 267-75 |
| PubMed ID | 21274006 | Mgi Jnum | J:332422 |
| Mgi Id | MGI:7425210 | Doi | 10.1038/embor.2011.2 |
| Citation | Ishiguro K, et al. (2011) A new meiosis-specific cohesin complex implicated in the cohesin code for homologous pairing. EMBO Rep 12(3):267-75 |
| abstractText | We identify a new mammalian cohesin subunit, RAD21-like protein (RAD21L), with sequence similarity to RAD21 and REC8. RAD21L localizes along axial elements in early meiotic prophase, in a manner that is spatiotemporally different to either REC8 or RAD21. Remarkably, RAD21L and REC8 have symmetrical, mutually exclusive localization on the not-yet-synapsed homologues, implying that the cohesin patterning could provide a code for homologue recognition. RAD21 transiently localizes to axial elements after the dissociation of RAD21L and REC8 in late pachytene, a period of recombination repair. Further, we show that the removal of cohesins and synaptonemal complex during late meiotic prophase is promoted by Polo-like kinase 1, which is similar to the mitotic prophase pathway. |
