| First Author | Tumpey TM | Year | 2007 |
| Journal | J Virol | Volume | 81 |
| Issue | 19 | Pages | 10818-21 |
| PubMed ID | 17652381 | Mgi Jnum | J:145260 |
| Mgi Id | MGI:3834047 | Doi | 10.1128/JVI.01116-07 |
| Citation | Tumpey TM, et al. (2007) The Mx1 gene protects mice against the pandemic 1918 and highly lethal human H5N1 influenza viruses. J Virol 81(19):10818-21 |
| abstractText | Mice carrying a wild-type Mx1 gene (Mx1+/+) differ from standard laboratory mice (Mx1-/-) in being highly resistant to infection with common laboratory strains of influenza A virus. We report that Mx1 also protects mice against the pandemic human 1918 influenza virus and a highly lethal human H5N1 strain from Vietnam. Resistance to H5N1 of Mx1+/+ but not Mx1-/- mice was enhanced if the animals were treated with a single dose of exogenous alpha interferon before infection. Thus, the interferon-induced resistance factor Mx1 represents a key component of the murine innate immune system that mediates protection against epidemic and pandemic influenza viruses. |
