| First Author | Liang B | Year | 1998 |
| Journal | Immunology | Volume | 93 |
| Issue | 4 | Pages | 462-8 |
| PubMed ID | 9659216 | Mgi Jnum | J:46902 |
| Mgi Id | MGI:1202217 | Doi | 10.1046/j.1365-2567.1998.00470.x |
| Citation | Liang B, et al. (1998) Injection of T-cell receptor peptide reduces immunosenescence in aged C57BL/6 mice. Immunology 93(4):462-8 |
| abstractText | Previous studies established that retrovirally infected young mice produced large amounts of autoantibodies to certain T-cell receptor (TCR) peptides whose administration diminished retrovirus-induced immune abnormalities. C57BL/6 young (4 weeks) and old (16 months) female mice were injected with these same synthetic human TCR V beta 8.1 or 5.2 peptides. Administration of these autoantigenic peptides to old mice prevent immunosenescence, such as age-related reduction in splenocyte proliferation and interleukin-2 (IL-2) secretion. TCR V beta peptide injection into young mice had no effect on T- or B-cell mitogenesis and IL-4 production while modifying tumour necrosis factor-alpha (TNF-alpha), IL-6, and interferon-gamma (IFN-gamma) secreted by mitogen-stimulated spleen cells. TCR V beta injection also retarded the excessive production of IL-4, IL-6 and TNF-alpha induced by ageing. These data suggest that immune dysfunction and abnormal cytokine production, induced by the ageing process, were largely prevented by injection of selected TCR V beta CDR1 peptides. |
