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Allele : Esyt2<tm1.3Sud> extended synaptotagmin-like protein 2; targeted mutation 1.3, Thomas C Sudhof
Primary Identifier  MGI:6101172 Allele Type  Targeted
Attribute String  Constitutively active Gene  Esyt2
Transmission  Germline Strain of Origin  C57BL/6NTac
Is Recombinase  false Is Wild Type  false
molecularNote  Flp-mediated excition of F3 sequences in Esyt2 resulted in the removal of the neomycin selection cassette and endogenous exon 10, leaving a mutant form (D4A) of exon 10. This allele expresses a constitutive mutant protein in which the four C2A-domain Ca(2+) binding sites of the C2A-domain are selectively abolished.
  • mutations:
  • Nucleotide substitutions,
  • Insertion
  • synonyms:
  • D4A,
  • D4A
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

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Trail: Allele




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