| Primary Identifier | MGI:109165 | Organism | mouse, laboratory |
| Chromosome | 6 | NCBI Gene Number | 14699 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.0.0) Predicted to enable G-protein beta-subunit binding activity and GTPase activity. Acts upstream of or within eye photoreceptor cell development; phototransduction; and protein localization. Predicted to be located in photoreceptor inner segment and photoreceptor outer segment. Predicted to be part of heterotrimeric G-protein complex. Is expressed in brain; retina; retina outer nuclear layer; and spleen. Orthologous to human GNGT1 (G protein subunit gamma transducin 1). PHENOTYPE: Homozygous null mice display markedly reduced flash sensitivity of individual retinal rods and gradual retinal photoreceptor degeneration with loss of most rods by 6 months of age. Homozygous knock-in mice expressing geranylgeranylated rod transducin exhibit impaired properties in light adaptation. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
