| Primary Identifier | IPR038281 | Type | Homologous_superfamily |
| Short Name | RTP801-like_C_sf |
| description | This superfamily represents the C-terminal domain of RTP801 (also known as REDD1), the protein product of a hypoxia-inducible factor 1 (HIF-1)- responsive gene []. It is thought to be involved in various cellular processes []. Both RTP801 and RTP801-like (REDD2) work downstream of AKT and upstream of TSC2 to inhibit mTOR, a serine/threonine kinase that plays an essential role in cell growth control []. Overexpression of RTP801 causes the apoptosis- resistant phenotype in cycling cells, and apoptosis sensitivity in growth arrested cells []. Two members of this superfamily expressed by Drosophila melanogaster, Scylla () and Charybde (), are designated as Hox targets [, ]. |
