| Primary Identifier | MGI:97172 | Organism | mouse, laboratory |
| Chromosome | 8 | NCBI Gene Number | 17750 |
| Mgi Type | protein coding gene |
| description | FUNCTION: Automated description from the Alliance of Genome Resources (Release 7.1.0) Predicted to enable cadmium ion binding activity and zinc ion binding activity. Acts upstream of or within several processes, including detoxification of copper ion; intracellular zinc ion homeostasis; and nitric oxide mediated signal transduction. Predicted to be located in cytosol. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including gut; liver lobe; lung; sensory organ; and telencephalon. Human ortholog(s) of this gene implicated in carotid stenosis and type 2 diabetes mellitus. Orthologous to several human genes including MT2A (metallothionein 2A). PHENOTYPE: Mice homozygous for null alleles of Mt1 and Mt2 exhibit increased sensitivity to xenobiotics and injury with decreased wound healing and abnormal mineral aborption. [provided by MGI curators] |
Features --> Cross References
Canonical gene --> CDSs in specific strains.
Canonical gene --> Exons in specific strains
Canonical gene --> Strain-specific IDs, biotypes, and locations
Canonical gene --> Transcripts in specific strains.
Features --> Overlapping features
